Chia Seeds
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Neuroprotective Properties:
Chia seeds are rich in bioactive peptides and polyphenols, which have been shown to exhibit neuroprotective effects. Peptide fractions derived from chia seeds, particularly the F1-3 kDa fraction, significantly reduce oxidative stress and inflammatory responses in microglial cells, which are pivotal in the pathogenesis of neurodegenerative diseases.Modulation of Neuroinflammatory Pathways:
The anti-inflammatory and antioxidant properties of chia seeds contribute to the modulation of proinflammatory mediators, such as TNFα and IL6, while reducing reactive oxygen species (ROS) production. These effects may help mitigate the neuroinflammation commonly associated with neurodegenerative disorders.Enhancement of Cognitive Function Through Cholinesterase Inhibition:
Chia seeds contain compounds such as quercetin, isoquercetin, and various polyphenols, which have demonstrated significant inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. This inhibition supports the maintenance of acetylcholine levels in the brain, a key neurotransmitter involved in cognitive processes such as memory and learning.Potential Role in Neurodegenerative Disease Prevention:
The combination of chia seeds' antioxidant, anti-inflammatory, and cholinesterase-inhibiting properties positions them as a promising functional food for the prevention and management of neurodegenerative diseases. Their bioactive components help modulate oxidative stress and inflammatory pathways, which are central to the development of cognitive decline and age-related neurodegeneration.
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